Researchers expecting to design better cures for kidney disease have turned their concentration in the lab to increasing clusters of kidney cells. The supposed organoids (developed from human stem cells) might assist cure damaged kidneys in individuals or can be employed to test drugs designed to battle kidney disease.
But new study in St. Louis from Washington University School of Medicine has verified rogue cells (namely muscle and brain cells) loitering inside kidney organoids. Such cells compose of just 10–20% of an organoid’s cells, the researchers found. But their presence means that the “recipes” employed to entice stem cells into turning kidney cells unintentionally are manufacturing other types of cell.
While at first glimpse the findings may be seen as a setback for employing kidney organoids as substitutes for human kidneys, there is still commitment. The scientists discovered a simple method to avoid most of those wayward cells from manufacturing, and that same method can be used by other researchers who find rogue cells in different organoids, such as those of the lung, brain, or heart. The research is posted in Cell Stem Cell.
On a related note, a group at the Medicine by Design of University of Toronto has merged the newest genomic tech with ML (machine learning) in a new research that clears doubt related brain stem cells, offering deep understanding that can one day assist the brain cure itself.
“This study informs us more related to how fully developed neural stem cells are generated in the brain. Theses stem cells are necessary for generating future medical therapies for nervous system and brain injuries,” claims a professor of molecular genetics & computer science at Donnelly Centre for Cellular and Biomolecular Research of University of Toronto and one of the study’s authors, Gary Bader, to the media in an interview.
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