Cancer Cells Defective Repair System Escorts Chaos In The Chromosomes

Cancer Cells Defective Repair System Escorts Chaos In The Chromosomes

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Researchers from the German Cancer Research Center have recently discovered a reason that results in a sequence of catastrophic events in the hereditary material of the cancerous cells which has been known for quite some time now.  As a result of the failure of a vital cellular DNA repair method there occurs numerous fragmentations and flawed assemblage of the genetic material. Thus, the researchers have now found a group of drugs which can be specifically used to treat the cancer cells with a repair defect. Sometime back, a team at the German Cancer Research Center was able to explain a novel pattern of damage taking place in the genetic material of tumor cells. The chaos observed in the nucleus of the cancerous cells in a child suffering from hard-line kind of brain tumor.

During the observation, it was detected that the parts of each chromosome were fragmented at various points and again reassembled wrongly which later showed certain sections missing, duplicated, or placed in the incorrect orientation. Such a condition is the first of its kind compared to the earlier known chromosome catastrophic genetic changes found in the tumorous cells. Such a chromosomal disorientation is known chromothripsis which is generally seen to occur in only about 20−30% of every cancer. According to Aurelie Ernst and her team, the chaos in the nucleus of the cancer cells is caused by the failure of the genetic repair systems. There are a number of environmental factors such as the UV rays known to cause defects in the DNA and there is a self-repair mechanism present in the cells to carry out the replacement process. The Myc oncogene, which is known to be a strong driver of cell growth, is copied on a high scale along with the chromothripsis which is followed by the replication of the damaged cells and chaos at the genomic level. This situation is seen mostly in the people suffering from brain tumors, melanomas, and breast cancer.

The repair defects causing chaos in the chromosome is difficult to cope with but there are drugs being developed for such cells which in later stages causes a complete death of such cells without harming the healthy cells. PARP inhibitors are being used to block a central DNA repair system since years. Now after clinical trial analysis, using it to treat chromothripsis could be a new therapeutic option in the future. The WHO has recently, however, confirmed that the overuse of the certain antibiotic drugs may result in the emergence of bacterial resistance in the future. In short, take prescribed drugs only and avoid cancer or other diseases from getting hold of you.